12 Chemistry Core Syllabus • Basics of nuclear structure and hybridisation • Bonding and structure, H-bonding in organic systems and electronegativity • Oxidation number and usage in Inorganic and organic chemistry • Equilibria, Le Chatelier’s principle and its applications • Solubility and Ksp calculations • Solubility curves and phase diagrams • Depression of freezing point and general colligative properties • Acid Base equilibria, application to proteins and other biological systems, buffering, pKa usage and Indicators • Buffering in the bloodstream • Rates – the rate equation and determination of rate law • Relation of rate law to mechanism • Arrhenius equation, activation energy, relationship to biological mechanism • Enzyme kinetics and development and use of Michaelis Menten equation • Raoult’s law • Entropy as a concept and Gibbs Free Energy • Use of ∆G=∆H-T∆S to predict reaction • Chemical potential and application to biological systems • Gibbs Free Energy profiles • Osmotic pressure, Osmolarity and finding protein RMM • Redox equilibria introduction • Use of electrode potentials in predicting reaction, Nearnst equation, Electrode potentials in biological systems • Principles of organic chemistry – Naming, Structure and Hybridisation • Isomerism in organic chemistry - Optical, Geometric, Conformational and Structural • Reactions of common groups and their properties • Chirality and its implications • Organic reaction mechanisms • Carbocation rearrangements • Substitution and Elimination reactions SN1, SN2 and E1, E2 • Resonance structures – Hemiacetals, Hemiketals and acid salts • Transamination • Peptide hydrolysis • The 4n+2 rule and aromatic systems • E / Z notation • Effect of substituent groups on the benzene ring • Fischer projections, Newman projections and other 3D considerations • Conformational isomerism • Cahn-Ingold-Prelog convention and the application to stereoisomerism • Assignment of true configuration to optical isomers R and S • Diels-Alder and related reactions • Sigmatropic rearrangements • Aldol formation and the Aldol condensation • The terpene structure as a base of larger organic molecules • Weiner Index • Bicyclic Nomenclature • Infrared Spectroscopy and NMR • Beer-Lambert Law • Ternary Diagrams • Fatty Acids and the Iodine rule • Sugars and Haworth projections A range of other degree level organic areas will be introduced and application to past questions will enforce concepts as they are covered. GENERAL CHEMISTRY Designed specifically for GAMSAT this guide will prepare you in the required theory and methods relating to General and Physical Chemistry. Developed from extensive experience and analysis of the examination, we provide you with the required knowledge, skills and techniques that GAMSAT demands in its application. Reinforced through constant testing and application to sample GAMSAT® problems to give you the best possible preparation. GRADMED expert GAMSAT preparation since 2002. GAMSAT Study Guide GENERAL CHEMISTRY GAMSAT® Study Guide GradMed GRADMED SINCE 2002 Copyright @ 2018 GradMed Limited. All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise except as noted below, without the permission of GradMed Limited. GAMSAT Study Guide - GENERAL CHEMISTRY
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